Poison ivy (Toxicodendron radicans) often grows as a ground cover until it finds a tree. It then becomes a long-lived deciduous vine. Resin in poison ivy leaves and stems causes severe itching that often persists for three weeks. Learn to recognize poison ivy's glossy three-leaflet leaves, and always wear gloves, long pants, and a long-sleeved shirt when working near it. Girdle mature vines by cutting them in several places with a sharp knife. Spray or brush a glyphosate herbicide on all poison ivy foliage within reach. Herbicides will weaken poison ivy, but monthly applications will be required to slowly kill it.